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位置: 首页> 品牌> Sigma-Aldrich> AhR Antagonist II, SR1-CAS 1227633-49-10-Calbiochem

AhR Antagonist II, SR1-CAS 1227633-49-10-Calbiochem

品牌
Sigma-Aldrich
CAS
1227633-49-9
货号
182706
规格纯度
The AhR Antagonist II, SR1 controls the biological activity of AhR. This small molecule/inhibitor is primarily used for Biochemicals applications.
价格
2538.8 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
1227633-49-9
AhR Antagonist II, SR1-CAS 1227633-49-10-Calbiochem
4-(2-(2-(Benzo[b]thiophen-3-yl)-9-isopropyl-9H-purin-6-ylamino)ethyl)phenol, 4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]phenol, StemRegenin 1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable purine compound that acts as a high affinity AhR antagonist (IC50= 127 nM against 3 nM TCDD-induced luciferase reporter activity in HepG2 cultures), but not a panel of 61 kinases. AhR expression and function knockouts by shRNAs, CH-223191 (Cat. No. 182705), or SR1 treatment all result in enhanced and sustained CD34+population in long-term proliferating/expanding cultures of cord blood-derived HSCs (hematopoietic setem cells) in serum-free media containing Tpo (Cat. No. 605218), SCF (Cat. No. 569600), Flt3 Ligand (Cat. No. 343010), and IL-6 (Cat. No. 407652) in a reversible manner. SR1 is reactive toward human, monkey, and canine, but not rat or murine, species.
A cell-permeable purine compound that acts as a high affinity (IC50= 40 nM against [125I]-N3Br2DD binding to human AhR) AhR antagonist (IC50= 127 nM against 3 nM TCDD-induced luciferase reporter activity in HepG2 cultures), while exhibiting little or no activity against a panel of 61 kinases. AhR expression and function knockouts by shRNAs, CH-223191 (Cat. No. 182705), or SR1 treatment all result in enhanced and sustained CD34+population in long-term proliferating/expanding cultures of cord blood-derived HSCs (hematopoietic setem cells) in serum-free media containing Tpo (Cat. No. 605218), SCF (Cat. No. 569600), Flt3 Ligand (Cat. No. 343010), and IL-6 (Cat. No. 407652) in a reversible manner (11- and 73-fold increase of total nucleated and CD34+cells, respectively, comparing 1 to 0 ?M SR1-treated cultures on day 21; 1118-fold increase in CD34+cells in 1 ?M SR1 cultures from day 0 to 21). SR1-expanded CD34+cells retain multilineage potential and the SR1-expanded progeny derived from 300 human CB CD34+cells are reported to exhibit the same level of engraftment efficiency as 10,000 unexpanded CB CD34+cells in NSG SCID micein vivo. SR1 is reactive toward human, monkey, and canine, but not rat or murine, species.

包装

5 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Boitano, A.E., et al. 2010.Science329,1345.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C24H23N5OS
分子量 429.54
MDL编号 MFCD16987861

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 white
溶解性 DMSO: 100 mg/mL
运输 wet ice
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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