AG 18-CAS 118409-57-7-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, reversible, substrate competitive protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC₅₀= 40 ?M) and the GTPase activity of transducin (IC₅₀= 10 ?M). Inhibits aldosterone secretion in response to angiotensin II. Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini. Also reported to inhibit guanylyl cyclase.
A broad-spectrum protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC₅₀= 40 ?M) and the GTPase activity of transducin (IC₅₀= 10 ?M). Inhibits aldosterone secretion in response to Angiotensin II (Cat. No. 05-23-0101). Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini.

包装

5 mg in Plastic ampoule

生化/生理作用

Primary Target
epidermal growth factor receptor autophosphorylation
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Target IC₅₀: 40 ?M against epidermal growth factor receptor autophosphorylation; 10 ?M against GTPase activity of transducin

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Jaleel, M., et al. 2004.Biochemistry43,8247.
Kapas, S., et al. 1995.Biochem. J.305,433.
Seger, R., et al. 1995.J. Biol. Chem.270,28325.
Williams, J.A. 1994.Am. J. Physiol.267,G401.
Geissler, J.F., et al. 1990.J. Biol. Chem.265,22255.
Levitzki, A. 1990.Biochem. Pharmacol.40,913.
Gazit, A., et al. 1989.J. Med. Chem.32,2344.
Lyall, R.M., et al. 1989.J. Biol. Chem.264,14503.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C10H6N2O2
分子量	186.17
MDL编号	MFCD00133899

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	yellow
溶解性	DMSO: 100 mg/mL ethanol: 50 mg/mL acetic acid: soluble
运输	ambient
储存温度	?20℃
InChI	1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H
InChI key	VTJXFTPMFYAJJU-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable