半岛bd体育手机客户端 说明
一般描述
Note: 5 ?mol = 2.23 mg.
Cell-permeable, potent, reversible, and metabolically stable antagonist of cAMP that is resistant to the action of mammalian cyclic nucleotide phosphodiesterases. Rp-8-Br-cAMPS is more lipophilic as compared to 8-Br-cAMP and Rp-cAMPS. In contrast to other common ATP-site inhibitors or to its parent compound Rp-cAMPS, Rp-8-Br-cAMPS discriminates between both isozymes of protein kinase A, preferring type I, thus providing additional selectivity. By occupying cAMP binding sites, prevents dissociation and activation of the kinase holoenzyme. λ
A potent, cell-permeable, and reversible metabolically-stable cAMP antagonist that inhibits cAMP-dependent protein kinase and shows preference for PKA type I. More lipophilic than cAMP antagonist Rp-cAMPS (Cat. No. 116814).
包装
5 μmol in Plastic ampoule
生化/生理作用
Cell permeable: yes
Primary Target
PKA 1
Product does not compete with ATP.
Reversible: yes
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Calaghan, S.C., et al. 1999.Pflugers Arch.437,780.
Gjertsen, B.T., et al. 1995.J. Biol. Chem.270,20599.
Yokozaki, H., et al. 1992.Cancer Res.52,2504.
Dostmann, W.R. et al. 1990.J. Biol. Chem.265,10484.
法律信息
Sold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C10H10BrN5O5PS · Na |
| 分子量 | 446.15 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥99% (HPLC) |
| 形式 | lyophilized |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) |
| 溶解性 | water: 40 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
