半岛bd体育手机客户端 说明
一般描述
A cell-permeable, potent, and selective activator of Wnt signaling that does not inhibit the activity of GSK-3β (IC50>60 ?M). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50= 700 nM in HEK-293T cells). Reported to cause substantial head defects duringXenopusembryonic development.
A cell-permeable pyrimidine compound that acts as a potent and selective activator of Wnt signaling without inhibiting the activity of GSK-3β (IC50>60 ?M). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50= 700 nM in HEK-293T cells), and cause substantial head defects duringXenopusembryonic development. Also available as a 10 mM solution in DMSO (Cat. No. 681664).
包装
5 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
EC50 = 700 nM inducing β-catenin and TCF (T-cell fate)-dependent transcriptional activity in HEK-293T cells
Primary Target
Selective activator of Wnt signaling
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Liu, J., et al. 2005.Angew. Chem. Int. Ed.44,1987.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C19H18N4O3 |
| 分子量 | 350.37 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid (sticky) |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | yellowish |
| 溶解性 | DMSO: 10 mg/mL ethanol: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
