半岛bd体育手机客户端 说明
一般描述
A cell-permeable quinoline compound that targets the nicotinamide-binding site and acts as a reversible sirtuin 2- (SIRT2) selective inhibitor (IC50= 3.5 ?M) with little activity against SIRT1/3 (IC50>50 ?M). Prevents cellular α-tubulin deacetylation in HeLa cells in a dose-dependent manner and with little cytotoxic effect. Shown to rescue α-Synuclein-mediated toxicity both in primary rat embryo midbrain culturesin vitroand in aDrosophilaPD modelin vivo. The inactive isomer AGK7 (Cat. No. 566326) can be used as a negative control.
包装
5 mg in Plastic ampoule
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
制备说明
Slight warming may be required for complete solubilization.
其他说明
Outerio, T.F., et al. 2007.Science317,516.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C23H13Cl2N3O2 |
| 分子量 | 434.27 |
| MDL编号 | MFCD01909444 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | yellow |
| 溶解性 | DMSO: 2.5 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
