半岛bd体育手机客户端 说明
一般描述
A cell-permeable acetohydrazide that dose-dependently inhibits hypoxia-induced mitochondrial ROS generation (≤ 10 ?M) in HepG2 and other cells, and suppresses cellular growth (≤ 50 ?M) in HUVEC, HeLa, and HCT15 cultures. At ≤ 10 ?M, this compound strongly inhibits VGFR-induced tube formation and invasive activity in HUVECsin vitrowithout obvious toxicity. It is also shown to hinder capillary formation in a chick embryo CAM assay without any sign of thrombosis and hemorrhagein vivo. Furthermore, it attenuates the expression levels HIF-1α and its target gene VEGF (0–10 ?M). dose-dependently.
A cell-permeable acetohydrazide that dose-dependently inhibits hypoxia-induced mitochondrial ROS generation (≤10 ?M) in HepG2 and other cells, and suppresses cellular growth (≤50 ?M) in HUVEC, HeLa, and HCT15 cultures. At ≤10 ?M, this compound strongly inhibits VGFR-induced tube formation and invasive activity in HUVECsin vitrowithout obvious toxicity. It is also shown to hinder capillary formation in a chick embryo CAM assay without any sign of thrombosis and hemorrhagein vivo. Furthermore, it attenuates the expression levels HIF-1α and its target gene VEGF (0–10 ?M) dose-dependently.
包装
5 mg in Glass bottle
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Kim, K.H., et al. 2011.Biochem. Biophys. Res. Commun.404,541.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C19H25N5O4S |
| 分子量 | 419.50 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | white |
| 溶解性 | DMSO: 50 mg/mL ethanol: soluble |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
