半岛bd体育手机客户端 说明
一般描述
A cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC50= 0.47 ?M) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC50= 0.35 ?M) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 ?M results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.
包装
5 mg in Glass bottle
Packaged under inert gas
警告
Toxicity: Regulatory Review (Z)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
其他说明
Kojetin, D., et al. 2010,Chem Bioin press
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C18H19NO3S2 |
| 分子量 | 361.48 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | >95% (HPLC) |
| 形式 | gum solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | white to yellow-brown |
| 溶解性 | DMSO: 25 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
