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位置: 首页> 品牌> Sigma-Aldrich> Monoacylglycerol Lipase Inhibitor II, Proteasome Inhibitor XV, NF-κB Activation Inhibitor IX, MAGL Inhibitor II

Pristimerin-CAS 1258-84-0-Calbiochem

品牌
Sigma-Aldrich
CAS
1258-84-0
货号
530070
规格纯度
A cell-permeable plant dienone-phenolic triterpenoid, naturally isolated fromtripterygium wilfordii.
价格
2165.23 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
1258-84-0
Pristimerin-CAS 1258-84-0-Calbiochem
Monoacylglycerol Lipase Inhibitor II, Proteasome Inhibitor XV, NF-κB Activation Inhibitor IX, MAGL Inhibitor II
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable plant dienone-phenolic triterpenoid, naturally isolated fromtripterygium wilfordii, whose inhibitory activities against proteasome chymotrypsin subunit (IC50= 2.2 and 3.0 ?M against purified rabbit 20S and human 26S proteasome, respectively) and cellular NF-κB pathway/IKK activation most likely account for its reported anticancer efficacy bothin vitro(IC50≤610 nM in A549, K562, KBM5, MCF-7, MDA-MB-231, HepG2, and primary human leukemia cell cultures) and in micein vivo(1 to 2.5 mg/kg/day, s.c.), including imatinib/STI571-resistant cancer cells harboring Bcr-Abl T315I mutation. Also reported to inhibit the activity of monoacylglycerol lipase (MGL), the enzyme that hydrolyzes and deactivates the cannabionoid receptor ligand 2-Arachidonoyl-sn-glycerol (2-AG), in a reversible manner with high potency (IC50= 93 nM).

包装

5 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他说明

Lu, Z., et al. 2010.Mol. Cancer9,112.
King, A.R., et al. 2009.Chem. Biol.16,1045.
Tiedemann, R.E., et al. 2009.Blood113,4027.
Yang, H., et al. 2008.J. Cell. Biochem.103,234.
Wu, C.C., et al. 2005.Mol. Cancer Ther.4,1277.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C30H40O4
分子量 464.64
MDL编号 MFCD01711331

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 red
溶解性 DMSO: 10 mg/mL
ethanol: 2.5 mg/mL
运输 ambient
储存温度 2-8℃
InChI 1S/C30H40O4/c1-18-19-8-9-22-28(4,20(19)16-21(31)24(18)32)13-15-30(6)23-17-27(3,25(33)34-7)11-10-26(23,2)12-14-29(22,30)5/h8-9,16,23,32H,10-15,17H2,1-7H3/t23-,26-,27-,28+,29-,30+/m1/s1
InChI key JFACETXYABVHFD-WXPPGMDDSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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