PKR Inhibitor-CAS 608512-97-6-Calbiochem

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一般描述

An imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC₅₀= 210 nM) and rescue PKR-dependent translation block (IC₅₀= 100 nM). Inactive control is also available (Cat. No. 527455). Shown to increase the late phase of long-lasting synaptic potentiation, and enhance long-term memory in mice. Also available as a 50 mM solution in DMSO (Cat. No. 527451).
An imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC₅₀= 210 nM) and rescue PKR-dependent translation block (IC₅₀= 100 nM). Shown to increase the late phase of long-lasting synaptic potentiation, and enhance long-term memory in mice. Inactive control is also available (Cat. No. 527455).

包装

5 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Primary Target
PKR
Target IC₅₀: 210 nM inhibiting RNA-induced PKR autophosphorylation and 100 nM in rescuing PKR-dependent translation block
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Carcinogenic / Teratogenic (D)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Zhu, P.J., et al. 2011.Cell147,1384.
Jammi, N.V., et al. 2003.Biochem. Biophys. Res. Commun.308,50.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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