PARP Inhibitor VI, NU1025-CAS 90417-38-2-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A potent inhibitor poly(ADP-ribose) polymerase (PARP; IC₅₀= 0.40 ?M). Has been shown to potentiate the cytotoxicity of the DNA-methylating agent MTIC [5-(3-N-methyltriazen-1-yl)-imidazole-4-carboxamide] and ionizing irradiation in murine L210 leukemia cells.
A potent poly(ADP-ribose) polymerase (PARP) inhibitor (IC₅₀= 400 nM) that potentiates the cytotoxicity of various DNA-active agents, including the DNA-methylating compound MTIC [5-(3-N-methyltriazen-1-yl)-imidazole-4-carboxamide], the DNA strand break-inducing drug temozolomide, topotecan, bleomycin, and ionizing radiation in murine L1210 leukemia cells, Chinese hamster ovary cells, and in a variety of human tumor cell lines.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Primary Target
PARP
Reversible: no
Cell permeable: no
Target IC₅₀: 0.4 ?M against poly(ADP-ribose) polymerase (PARP)

警告

Toxicity: Standard Handling (A)

制备说明

This solution can be further diluted 1:100 in tissue culture medium before use.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Delaney, C.A., et al. 2000.Clin. Cancer Res.6,2860.
Boulton, S., et al. 1999.Carcinogenesis20,199.
Bowman, K.J., et al. 1998.Br. J. Cancer78,1269.
Griffin, R.J., et al. 1998.J. Med. Chem.41,5247.
Griffin, R.J., et al. 1996.Pharm. Sci.2,43.
Boulton, S., et al. 1995.Br. J. Cancer72,849.
Griffin, R.J., et al. 1995.Anticancer Drug Res.10,507.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C9H8N2O2
分子量	176.17
MDL编号	MFCD00942555

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	off-white
溶解性	DMSO: 25 mg/mL
运输	ambient
储存温度	?20℃
InChI	1S/C9H8N2O2/c1-5-10-8-6(9(13)11-5)3-2-4-7(8)12/h2-4,12H,1H3,(H,10,11,13)
InChI key	YJDAOHJWLUNFLX-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3