Oridonin,R. rubescens-CAS 28957-04-2-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable inhibitor of NF-κB activity that displays antiproliferative (ED₅₀~ 2.7 ?g/ml in lymphoid malignant cells) and antiangiogenic properties (significantly inhibits network formation of HMEC-1 cells at 2.5 ?g/ml). Reported to affect DNA synthesis, induce apoptosis, and initiate cell cycle arrest. Shown to efficiently block both TNF-α and LPS-induced NF-κB activity in Jurkat and in RAW264.7 murine macrophages. Also inhibits p65 NF-κB transcriptional activity (IC₅₀~5 ?g/ml in MT-1 cells) by disrupting NF-κB DNA-binding activity without interfering with its nuclear translocation.
A cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative (ED₅₀= ~ 2.7 ?g/ml in lymphoid malignant cells) and antiangiogenic properties (significantly inhibits network formation of HMEC-1 cells at 2.5 ?g/ml). Reported to affect DNA synthesis, induce apoptosis and initiate cell cycle arrest. Shown to efficiently block both TNF-α and LPS-induced NF-κB activity in Jurkat and in RAW264.7 murine macrophages, and inhibit p65 NF-κB transcriptional activity (IC₅₀= ~ 5 ?g/ml in MT-1 cells) by disrupting NF-κB DNA-binding activity without interfering with its nuclear translocation.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
NF-κB transcriptional activity
Target IC₅₀: 5 ?g/ml inhibiting p65 NF-κB transcriptional activity in MT-1 cells
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

重悬

Use only fresh DMSO for reconstitution.

其他说明

Ikezoe, T., et al. 2005.Mol. Cancer Ther.4,578.
Meade-Tollin, L.C., et al. 2004.J. Nat. Prod.67,2.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C20H28O6
分子量	364.43

半岛bd体育手机客户端 性质

质量水平	100
测定	≥93% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	yellow
溶解性	DMSO: 10 mg/mL
运输	wet ice
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable