MNK1 Inhibitor-CAS 522629-08-9-Calbiochem

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一般描述

A cell-permeable, reversible, and ATP-competitive pyrazolo-pyrimidine compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1; IC₅₀= 2.2 ?M) with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. Effectively inhibits eIF4E phosphorylation (IC₅₀= 3 ?M) by MNK1 in 293 human embryonic kidney cells and serves as a useful tool in studying MNK1-mediated cellular signaling.

生化/生理作用

Cell permeable: yes
Product competes with ATP.
Primary Target
Mitogen-activated protein kinase-interacting kinase 1 (MNK1)
Reversible: yes
Target IC₅₀: 2.2 ?M against mitogen-activated protein kinase-interacting kinase 1 (MNK1); 3 ?M against eIF4E phosphorylation by MNK1 in 293 human embryonic kidney cells

包装

Packaged under inert gas

警告

Toxicity: Toxic (F)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Topisirovic, I., et al. 2004.Cancer Res.64,8639.
Worch, J., et al. 2004.Oncogene23,9162.
Walsh, D., and Mohr, I. 2004.Genes Dev.18,660.
Morley, S.J., and Naegele, S. 2002.J. Biol. Chem.277,32855.
Knauf, U., et al. 2001.Mol. Cell. Biol.21,5500.
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法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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