MMP-12 Inhibitor, MMP408-CAS 1258003-93-8-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A dibenzofuranylsulfanamido-valine compound that acts as a potent, active site zinc-targeting, MMP-12-selective inhibitor (IC₅₀= 2 nM against human MMP-12) with much weaker activity against MMP-12 from mouse/rat/sheep species (IC₅₀= 160, 320 and 22.3 nM, respectively) or human MMP-3/13/14 (IC₅₀= 351, 120 and 1100 nM , respectively), and practically ineffective toward human Agg-1/2 (IC₅₀>5 ?M), TACE (IC₅₀>25 ?M), and MMP-1/7 (IC₅₀>6 ?M). MMP408 is orally active in mice and shown to effectively alleviate rhMMP-12-induced pulmonary inflammatory response in micein vivoby more than 50% (5 mg/kg, p.o., b.i.d.).
A dibenzofuranylsulfanamido-valine compound that acts as a potent, active site zinc-targeting, MMP-12-selective inhibitor (IC₅₀= 2 nM against human MMP-12) with much weaker activity against MMP-12 from mouse/rat/sheep species (IC₅₀= 160, 320 and 22.3 nM , respectively) or human MMP-3/13/14 (IC₅₀= 351, 120 and 1100 nM , respectively), and practically ineffective toward human Agg-1/2 (IC₅₀>5 ?M), TACE (IC₅₀>25 ?M), and MMP-1/7 (IC₅₀>6 ?M). MMP408 is orally active in mice and shown to effectively alleviate rhMMP-12-induced pulmonary inflammatory response in micein vivoby more than 50% (5 mg/kg, p.o., b.i.d.).

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Li, W., et al. 2009.J. Med. Chem.52,1799.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

半岛bd体育手机客户端 性质

安全信息