Luciferase Inhibitor II-CAS 10205-56-8-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A 2-arylbenzothiazole compound that acts as an inhibitor against the ATP-dependentPhotinus pyralis(lucPpy) andPhoturis pennsylvanica(lucPpe) luciferase activity (IC₅₀= 0.2 and 0.32 ?M, respectively, with 10 ?M ATP, 10 ?M luciferin, and 10 nM respective enzyme). Unlike Luciferase Inhibitor I (Cat. No. 119113), Luciferase Inhibitor II is competitive with respect to luciferin and exhibits reduced potency againstlucPpe-based commercial luciferase-luciferin formulations with high luciferin concentration (IC₅₀= 10 ?M against Promega′s Kinase-Glo ; ineffective against Kinase-Glo Plus and Kinase-Glo Max; at a 3-fold formulation dilution and 6.77 ?M ATP).
A 2-arylbenzothiazole compound that acts as an inhibitor against the ATP-dependentPhotinus pyralis(lucPpy) andPhoturis pennsylvanica(lucPpe) luciferase activity (IC₅₀= 0.2 and 0.32 ?M, respectively, with 10 ?M ATP, 10 ?M luciferin, and 10 nM respective enzyme). Unlike Luciferase Inhibitor I (Cat. No. 119113), Luciferase Inhibitor II is competitive with respect to luciferin and exhibits reduced potency againstlucPpe-based commercial luciferase-luciferin formulations with high luciferin concentration (IC₅₀= 10 ?M against Promega′s Kinase-Glo ; ineffective against Kinase-Glo Plus and Kinase-Glo Max; at a 3-fold formulation dilution and 6.77 ?M ATP).

包装

5 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Auld, D.S., et al. 2009.J. Med. Chem.52,1450.
Auld, D.S., et al. 2008.J. Med. Chem.51,2372.

法律信息

Marketed by Promega Corp. under the registered trademarks.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C15H14N2S
分子量	254.35

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	pale green
溶解性	DMSO: 0.5 mg/mL ethanol: 3 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C15H14N2S/c1-17(2)12-9-7-11(8-10-12)15-16-13-5-3-4-6-14(13)18-15/h3-10H,1-2H3
InChI key	HYKGLCSXVAAXNC-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable