半岛bd体育手机客户端 说明
一般描述
A cell-permeable compound that acts as a selective, potent, and reversible inhibitor of non-muscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤100 ?M) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly.
包装
5 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
ATPase
Product does not compete with ATP.
Target IC50: <100 ?M inhibiting the ATPase and gliding motility of human platelets
Reversible: yes
警告
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
外形
A 50 mM (5 mg/342 ?l) solution of (±)-Blebbistatin (Cat. No. 203390) in 90% DMSO.
重悬
Following initial thaw, aliquot and freeze (-20°C).
其他说明
Shu, S., et al. 2005.Proc. Natl. Acad. Sci. USA102,1472.
Kovacs, M., et al. 2004.J. Biol. Chem.279,35557.
Straight, A.F., et al. 2003.Science299,1743.
Cheung, A., et al. 2001.Mol. Biol. Cell Suppl.12,271a.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C18H16N2O2 |
| 分子量 | 292.33 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥97% (HPLC) |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
Sigma-Aldrich
m.cnreagent.com
