半岛bd体育手机客户端 说明
一般描述
A cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC50= 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC50>10 ?M), including lck and src. The solid form of this compound (Cat. No. 407601) is also available.
包装
5 mg in Glass bottle
Packaged under inert gas
生化/生理作用
Primary Target
IRAK-1/4
Target IC50: 300 nM and 200 nM for IRAK-1 and -4
Reversible: yes
警告
Toxicity: Irritant (B)
外形
A 25 mM (5 mg/506 ?L) solution of Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor (Cat. No. 407601) in DMSO.
重悬
Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
其他说明
Srivastava, R., et al. 2012.Cancer Res.72,In press.
Bhattacharyya, S., et al. 2007.Am. J. Physiol. Gastrointest. Liver Physiol.293,G429.
Powers, J.P., et al. 2006.Bioorg. Med. Chem. Lett.16,2842.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C20H21N5O4 |
| 分子量 | 395.41 |
| MDL编号 | MFCD09752602 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light |
| 运输 | dry ice |
| 储存温度 | ?70℃ |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 2 |
| 闪点(F) | 188.6 °F - (refers to pure substance) |
| 闪点(C) | 87 ℃ - (refers to pure substance) |
Sigma-Aldrich
m.cnreagent.com
