半岛bd体育手机客户端 说明
一般描述
A cell-permeable, highly selective, ATP/GTP-competitive casein kinase II (CKII) inhibitor (IC50= 900 nM and 1.6 ?M for rat liver and human recombinant CKII, respectively) and DYRK (IC50<1 ?M for DYRK1a). Specificity for CKII has been reported following the screening of 33 kinases, including PKA, Akt, PKC, MKK1, ERK2, p38, JNK, Lck, Lyn, and Syk. Also reported to inhibit NS3-associated viral helicase activity in hepatitis C virus (HCV) (IC50= 20 and 60 ?M using DNA and RNA substrates, respectively) and West Nile virus (WNV) (IC50= 1.7 ?M and 900 nM using DNA and RNA substrates, respectively).
包装
5 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Reversible: yes
Cell permeable: yes
Primary Target
CK2 rat liver, human recombinant
Product competes with ATP.
Target IC50: 900 nM and 1.6 ?M, using rat liver and human recombinant CK2, respectively
警告
Toxicity: Carcinogenic / Teratogenic (D)
外形
A 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218697) in DMSO.
重悬
Following initial use, aliquot and refrigerate (4°C).
分析说明
Single spot by TLC
其他说明
Borowski, P., et al. 2003.Eur. J. Biochem.270,1645.
Zien, P., et al. 2003.Biochem. Biophys. Res. Commun.306,129.
Sarno, S., et al. 2003.Biochem. J.374,639.
Sarno, S., et al. 2001.FEBS Lett.496,44.
Szyszka, R., et al. 1995.Biochem. Biophys. Res. Commun.208,418."
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C6HBr4N3 |
分子量 | 434.71 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
形式 | liquid |
manufacturer/tradename | Calbiochem? |
储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
运输 | wet ice |
储存温度 | 2-8℃ |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 2 |
闪点(F) | 188.6 °F - (Dimethylsulfoxide) |
闪点(C) | 87 ℃ - (Dimethylsulfoxide) |
Sigma-Aldrich