半岛bd体育手机客户端 说明
一般描述
Potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50= 100 nM). Jak family tyrosine kinase inhibitor. Inhibition of Jak2 by AG 490 selectively blocks leukemic cell growthin vitroandin vivoby inducing programmed cell death, with no harmful effect on normal haematopoiesis. Inhibits the constitutive activation of STAT-3 and IL-2-induced growth of MF tumor cells. AG 490 has also been shown to inhibit the autokinase activity of JAK3. Also reported to inhibit guanylyl cyclase.
包装
5 mg in Plastic ampoule
Packaged under inert gas
警告
Toxicity: Irritant (B)
外形
A 100 mM (5 mg/170 ?l) solution of AG490 (Cat. No. 658401) in DMSO.
重悬
Following initial thaw, aliquot and freeze (-70°C). Once opened, stock solution is stable for up to 6 months at -70°C.
其他说明
Jaleel, M., et al. 2004.Biochemistry43,8247.
Eriksen, K.W., et al. 2001.Leukemia15,787.
Kirken, R.A., et al. 1999.Leukoc. Biol.65,891.
Nielsen, M., et al. 1997.Proc. Natl. Acad. Sci. USA94,6764.
Meydan, N., et al. 1996.Nature379,645.
Gazit, A., et al. 1991.J. Med. Chem.34,1896.
Levitzki, A. 1990.Biochem. Pharmacol.40,913.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C17H14N2O3 |
| 分子量 | 294.30 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 运输 | wet ice |
| 储存温度 | ?70℃ |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 3 |
| 闪点(F) | 188.6 °F - (Dimethylsulfoxide) |
| 闪点(C) | 87 ℃ - (Dimethylsulfoxide) |
Sigma-Aldrich
m.cnreagent.com
