半岛bd体育手机客户端 说明
一般描述
A cell-permeable, thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP-competitive inhibitor of GSK-3β (IC50= 2 ?M). Inhibits Flt-3 and PKC activities (IC50= 673 nM and 1.4-5.5 ?M, respectively). Does not significantly affect the activities of Cdk1/cyclin B, CK-II, PKA, or PKC (IC50>100 ?M). Shown to inhibit collagen- and thrombin-induced platelet aggregation.
A thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3β (IC50= 2 ?M). Inhibits Flt-3 and PKC activities (IC50= 673 nM and 1.4-5.5 ?M, respectively). Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, and PKA, (IC50>100 ?M). Binds to the active site of GSK-3β.
包装
5 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Primary Target
Gsk-3β
Target IC50: 2 ?M, 673 nM, 1.4-5.5 ?M, against GSK-3β, Flt-3, and PKC activities, respectively
Product does not compete with ATP.
Reversible: no
Cell permeable: no
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Guzman, M.L., et al. 2007.Blood110,4436.
Barry, F.A., et al. 2003.FEBS Lett.553,173.
Martinez, A., et al. 2002.J. Med. Chem.45,1292.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C10H10N2O2S |
| 分子量 | 222.26 |
| MDL编号 | MFCD04973552 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | white to off-white |
| 溶解性 | DMSO: 10 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
Sigma-Aldrich
m.cnreagent.com
