Ginkgolic Acid (15:1)-CAS 22910-60-7-Calbiochem

半岛bd体育手机客户端名称：

22910-60-7
Ginkgolic Acid (15:1)-CAS 22910-60-7-Calbiochem
(Z)-6-(Pentadec-8-enyl)-2-hydroxybenzoic acid, Histone Acetyltransferase Inhibitor VI, PCAF Inhibitor II, SUMOylation Inhibitor, HAT Inhibitor VI
Histone Acetyltransferase Inhibitor VI, PCAF Inhibitor II, SUMOylation Inhibitor, (Z)-6-(Pentadec-8-enyl)-2-hydroxybenzoic acid, HAT Inhibitor VI

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A cell-permeable anacardic acid (Cat. No. 172050) analog that inhibits protein SUMO (Cat. Nos. 662037, 662039, and 662042) modification (IC₅₀= 3.0 ?M using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. Nos. 662073 and 662074) and interfering with E1-SUMO intermediate formation independent of E1 active site cysteine. Both ginkgolic acid and anacardic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins, including p53, in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although both compounds are shown to inhibit histone lysine acetylation by PCAF (Cat. No. 124026) in cell-free acetylase assays. Also available as a 25 mM solution in DMSO (Cat. No. 508197).
A cell-permeable anacardic acid (Cat. No. 172050) analog that inhibits protein SUMO (Cat. No. 662037, 662039, and 662042) modification (IC₅₀= 3.0 ?M using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. No. 662073 and 662074) and interfering with E1-SUMO intermediate formation independent of E1 active site cysteine. Both ginkgolic acid and anacardic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins, including p53, in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although both compounds are shown to inhibit histone lysine acetylation by PCAF (Cat. No. 124026) in cell-free acetylase assays.

包装

5 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Irritant (B)

重悬

Following intitial thaw, aliquot and freeze (-20°C).

其他说明

Fukuda, I., et al. 2009.Chem. Biol.16,133.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₂H₃₄O₃
分子量	346.50
MDL编号	MFCD03093717

半岛bd体育手机客户端性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze protect from light
颜色	white
溶解性	DMSO: 100 mg/mL ethanol: 100 mg/mL
运输	ambient
储存温度	?20℃
InChI	1S/C22H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h7-8,15,17-18,23H,2-6,9-14,16H2,1H3,(H,24,25)/b8-7-
InChI key	YXHVCZZLWZYHSA-FPLPWBNLSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H317 - H413
预防措施声明	P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
危险分类	Aquatic Chronic 4 - Skin Sens. 1
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	509.9 °F - (calculated)
闪点(C)	265.5 ℃ - (calculated)