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位置: 首页> 品牌> Sigma-Aldrich> EIF2AK3 Activator, CCT020312-Calbiochem

EIF2AK3 Activator, CCT020312-Calbiochem

品牌
Sigma-Aldrich
货号
324879
规格纯度
The EIF2AK3 Activator, CCT020312 modulates the biological activity of EIF2AK3.
价格
2635.53 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
EIF2AK3 Activator, CCT020312-Calbiochem
6-Bromo-3-[5-(4-bromo-phenyl)-1-(3-diethylamino-propionyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-phenyl-1H-quinolin-2-one, PERK activator, CCT020312
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A dihydropyrazol derivative that acts as a selective activator of eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3/PERK) and increases the phosphorylation of EIF2A at Ser51 in HT29 and MCF7 cells. Does not inhibit the activity of cyclin dependent kinases, but causes a rapid loss of cyclin D expression. Also shown to block Rb protein phosphorylation (EC50= 4.2 ?M) in HT29 cells. Reported to sensitize cancer cells with defective taxane-induced EIF2A phosphorylation to paclitaxel treatment. Induces a long-term inhibition of cell proliferation even after its removal (GI50= 3.1 ?M).

包装

5 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Stockwell, S. R., et al. 2011.Plos OneIn press.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C31H30Br2N4O2
分子量 650.40
MDL编号 MFCD01004667

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 yellow-white
溶解性 DMSO: 50 mg/mL
运输 ambient
储存温度 ?20℃
SMILES string O=C1C(C2=NN(C(CCN(CC)CC)=O)C(C3=CC=C(Br)C=C3)C2)=C(C4=CC=CC=C4)C5=CC(Br)=CC=C5N1

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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