E-4031-CAS 113558-89-7-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A potent and selective inhibitor of the inactivating inward-rectifying potassium current (IK,IR) (IC₅₀= 10 nM). In inside-out patches, E-4031 also blocks ATP sensitive K⁺channel (EC₅₀= 31 ?M). A specific blocker of cardiac HERG channels (IC₅₀= 7.7 nM). A class III anti-arrhythmic agent with differential atrial versus ventricular activity.
A potent and selective inhibitor of the rapid type of inactivating inward-rectifying K⁺current (IK, IR) (IC₅₀= 10 nM). A class III anti-arrhythmic agent with differential atrial versus ventricular activity. A specific blocker of HERG channels (IC₅₀= 7.7 nM).

包装

5 mg in Glass bottle

生化/生理作用

Primary Target
Inhibitor of the rapid type of inactivating inward-rectifying K+ current
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 10 nM inhibiting the rapid type of inactivating inward-rectifying K+ current
Cell permeable: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Ficker, E., et al. 2000.Am. J. Physiol.279,H1748.
Ono, K., et al. 2000.J. Physiol. (London)524 (Pt. 1),51.
Xie, J.T., et al. 2000.Methods Find. Exp. Clin. Pharmacol.22,67.
Bauer, C.K., et al. 1999.Mol. Cell Endocrinol.148,37.
Baskin, E.P., and Lynch, J.J. 1998.J. Pharmacol. Exp. Ther.285,135.
Weinsberg, F., et al. 1997.Pflugers Arch.434,1.
West, P.D., et al. 1997.J. Cardiovasc. Pharmacol. Ther.2,205.
West, P.D., et al. 1996.Pharmacol. Toxicol.78,89.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C21H27N3O3S · 2HCl · 2H2O
分子量	510.47

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated (hygroscopic)
颜色	white to off-white
溶解性	DMSO: 50 mg/mL water: 50 mg/mL
运输	ambient
储存温度	?20℃
InChI	1S/C21H27N3O3S/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27/h3-9,18,23H,10-15H2,1-2H3
InChI key	SRUISGSHWFJION-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable