Diacylglycerol Kinase Inhibitor I-CAS 93076-89-2-Calbiochem

品牌

Sigma-Aldrich

CAS

93076-89-2

货号

266785

包装型号

5 MG, The Diacylglycerol Kinase Inhibitor I, also referenced under CAS 93076-89-2, controls the biological activity of Diacylglycerol Kinase. This small molecule/inhibitor is primarily used for Phosphorylat

规格纯度

The Diacylglycerol Kinase Inhibitor I, also referenced under CAS 93076-89-2, controls the biological activity of Diacylglycerol Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

价格

2165.23 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

93076-89-2
Diacylglycerol Kinase Inhibitor I-CAS 93076-89-2-Calbiochem
R59022, 6-{2-{4-[( p-Fluorophenyl)phenylmethylene]-1-piperidinyl}ethyl}-7-methyl-5H-thiazolo(3,2-a)pyrimidine-5-one
6-{2-{4-[( p-Fluorophenyl)phenylmethylene]-1-piperidinyl}ethyl}-7-methyl-5H-thiazolo(3,2-a)pyrimidine-5-one, R59022

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

Potentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. Inhibits diacylglycerol kinase (IC₅₀= 2.8 ?M) without affecting phosphodiesterase or phosphatidylinositol kinase. Potentiates this effect in studies of signal-transducing inositol lipid metabolism. Inhibits human platelet DAG kinase in intact cells (IC₅₀= 3.6 ?M) and in isolated membranes (IC₅₀= 6.7 ?M). In porcine thymus cytosol it inhibits the 80 kDa DAG kinase (IC₅₀= 10 ?M) but has no effect on the 150 kDa DAG kinase. Weak dopamine D₂and histamine H₁antagonist and strong serotonin-S₂antagonist.
Potentiates the activity of protein kinase C by inhibiting diacylglycerol metabolism. Inhibits diacylglycerol kinase (IC₅₀= 2.8 ?M) without affecting phosphodiesterase or phosphatidylinositol kinase. Weak dopamine D₂and histamine H₁antagonist and strong serotonin S₂antagonist.

包装

5 mg in Plastic ampoule

生化/生理作用

Primary Target
Diacylglycerol Kinase
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.

其他说明

Goin, M., et al. 1993.FEBS Lett.316,68.
Ohtsuka, T., et al. 1990.J. Biol. Chem.265,15418.
de Chaffoy de Courcelles, D., et al. 1985.J. Biol. Chem.260,15762.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₇H₂₆FN₃OS
分子量	459.58
MDL编号	MFCD00055114

半岛bd体育手机客户端性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze
颜色	white
溶解性	ethanol: 12 mg/mL DMSO: 4 mg/mL
运输	ambient
储存温度	10-30℃
InChI	1S/C27H26FN3OS/c1-19-24(26(32)31-17-18-33-27(31)29-19)13-16-30-14-11-22(12-15-30)25(20-5-3-2-4-6-20)21-7-9-23(28)10-8-21/h2-10,17-18H,11-16H2,1H3
InChI key	MFVJXLPANKSLLD-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable