D-erythro-Sphingosine, N,N-Dimethyl--CAS 119567-63-4-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable and reversible inhibitor of protein kinase C (IC₅₀= 12 ?M) and enhances src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells.
A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC₅₀= 12 ?M) and stimulates Src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells. An inhibitor of sphingosine kinase.

包装

5 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Target IC₅₀: 12 ?M against PKC
Reversible: yes
Primary Target
PKC

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

其他说明

Cuvillier, O., et al. 1996.Nature381,800.
Ohta, H., et al. 1995.Cancer Res.55,691.
Kimura, S., et al. 1992.Biochem. Pharmacol.44,1585.
Hanada, K., et al. 1991.Biochemistry30,11682.
Igarashi, Y., et al. 1990.J. Biol. Chem.265,5385.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C20H41NO2
分子量	327.55

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (TLC)
形式	oil (Clear) waxy solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze
溶解性	DMSO: 5 mg/mL ethanol: soluble methanol: soluble
运输	ambient
储存温度	?20℃
InChI	1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1
InChI key	YRXOQXUDKDCXME-YIVRLKKSSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable