D-erythro-Sphingosine, N-Acetyl--CAS 3102-57-6-Calbiochem

半岛bd体育手机客户端 说明

一般描述

Biologically active, cell-permeable, non-physiological ceramide analog. Inhibits cell growth and induces apoptosis in HL-60 cells. Induces intranucleosomal DNA fragmentation. An activator of heterotrimeric protein phosphatase 2A (PP2A). Stimulates a cytosolic serine/threonine protein phosphatase in T9 cells at concentrations as low as 100 nM. Activates stress activated protein kinase (SAPK) in HL-60 human promyelocytic cells.
Biologically active, cell-permeable, non-physiological ceramide analog. Inhibits cell growth and induces apoptosis of HL-60 cells. Induces intranucleosomal DNA fragmentation. An activator of heterotrimeric protein phosphatase 2A. Stimulates a cytosolic serine/threonine protein phosphatase in T9 cells at concentrations as low as 100 nM. Activates stress-activated protein (SAP) kinase in HL-60 human promyelocytic cells.

包装

5 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
Inhibits cell growth and induces apoptosis in HL-60 cells

警告

Toxicity: Irritant (B)

制备说明

When diluting into aqueous solution, sonication may be necessary to achieve a uniform suspension.

重悬

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Alcohol stock solutions are stable for <1 week at -20°C.

其他说明

Westwick, J.K., et al. 1995.J. Biol. Chem.270,22689.
Cifone, M.G., et al. 1994.J. Exp. Med.180,1547.
Hannun, Y.A. 1994.J. Biol. Chem.269,3125.
Bielawska, A., et al. 1993.J. Biol. Chem.268,26226.
Obeid, L.M., et al. 1993.Science259,1769.
Ballou, L.R., et al. 1992.J. Biol. Chem.267,20044.
Dobrowsky, R.T., and Hannun, Y.A. 1992.J. Biol. Chem.267,5048.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C20H39NO3
分子量	341.53

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (TLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze
颜色	white to off-white
溶解性	DMSO: 25 mg/mL ethanol: 5 mg/mL methanol: 5 mg/mL
运输	ambient
储存温度	?20℃
InChI	1S/C20H39NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20(24)19(17-22)21-18(2)23/h15-16,19-20,22,24H,3-14,17H2,1-2H3,(H,21,23)/b16-15+/t19-,20+/m0/s1
InChI key	BLTCBVOJNNKFKC-QUDYQQOWSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable