半岛bd体育手机客户端 说明
一般描述
A cell-permeable potent, selective inhibitor of cyclooxygenase-2 (COX-2) (IC50= 650 nM, human monocytes COX-2). Shown to specifically inhibit COX-2 in human whole blood (IC50= 4.3 ?M). Displays only weak inhibitory activity against COX-1 from human platelets (19% inhibition at 10 ?M) and in whole blood (25% inhibition at 100 ?M).
A cell-permeable potent and selective inhibitor of COX-2 from human monocytes (IC50= 650 nM) and in whole blood (IC50= 4.3 ?M). Displays only very weak activity against COX-1 from human platelets (IC50>10 ?M) and in whole blood (IC50>100 ?M).
包装
5 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Target IC50: 650 nM against COX-2 from human monocytes; 4.3 ?M against COX-2 in whole blood
Primary Target
COX-2 from human monocytes
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Palomer, A., et al. 2002.J. Med. Chem.45,1402.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C18H16ClNO4S |
| 分子量 | 377.84 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥97% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | white |
| 溶解性 | methanol: 1 mg/mL DMSO: 100 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
