CFTR Inhibitor-172-CAS 307510-92-5-Calbiochem

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一般描述

A cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl^-transport in human airway cells (K_i~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl^-channels, MDR-1, ATP-sensitive K⁺channels, or a series of other transporters even at concentrations as high as 5 ?M. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas.
A cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl^-transport in human airway cells (K_i~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl^-channels, MDR-1, ATP-sensitive K⁺channels, or a series of other transporters even at concentrations as high as 5 ?M. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. Also available as a 50 mM solution in DMSO (Cat. No. 219674).

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target K_i: ~ 300 nM against CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells
Product does not compete with ATP.
Reversible: yes
Primary Target
CFTR

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Yang, H., et al. 2003.J. Biol. Chem.278,35079.
Al-Awqati, Q., et al. 2002.J. Clin. Invest.110,1599.
Ma, T., et al. 2002.J. Clin. Invest.110,1651.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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