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位置: 首页> 品牌> Sigma-Aldrich> CCR2 Antagonist-CAS 445479-97-0-Calbiochem

CCR2 Antagonist-CAS 445479-97-0-Calbiochem

品牌
Sigma-Aldrich
CAS
445479-97-0
货号
227016
规格纯度
The CCR2 Antagonist, also referenced under CAS 445479-97-0, controls the biological activity of CCR2.
价格
3124.36 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
445479-97-0
CCR2 Antagonist-CAS 445479-97-0-Calbiochem
2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Acis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC50= 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca+2flux and chemotaxis (IC50= 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 ?M). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding.

包装

5 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

制备说明

Gentle warming, rapid stirring, and/or sonication may be required for complete solubilization.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Cherney, R.J., et al. 2008.J. Med. Chem.51,721.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C28H34F3N5O4S
分子量 593.66

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥97% (racemic mixture, HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
desiccated (hygroscopic)
protect from light
颜色 white
溶解性 ethanol: 6 mg/mL
DMSO: 60 mg/mL
运输 ambient
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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