Cathepsin K Inhibitor I-Calbiochem

品牌

Sigma-Aldrich

货号

219377

包装型号

5 MG, The Cathepsin K Inhibitor I controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

规格纯度

The Cathepsin K Inhibitor I controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

价格

3736.22 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

Cathepsin K Inhibitor I-Calbiochem
1,3-Bis(CBZ-Leu-NH)-2-propanone, 1,3-Bis(N-carbobenzoyloxy-L-leucyl)amino Acetone

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A cell-permeable, symmetrical bis(acylamino)ketone that acts as a potent, selective, and reversible inhibitor of cathepsin K (K_i,app= 22 nM). Shown to bind to cathepsin K and span both the S- and S′-subsites. A poor inhibitor of papain (K_i,app>10 ?M) but displays greater selectivity towards other proteases of the papain family (K_i,app= 340 nM, 890 nM, and 1.3 ?M for cathepsin L, cathepsin S, and cathepsin B respectively). Inhibits trypsin and chymotrypsin activities only at higher concentrations (K_i,app≥ 50 ?M).
A cell-permeable, symmetrical bis(acylamino)ketone compound that acts as a potent, selective, reversible inhibitor of cathepsin K (K_i,= 22 nM). Also shown to inhibit cathepsin K in stably transfected CHO cells (IC₅₀= 134 nM). Reported to bind to cathepsin K and span both the S- and S′- subsites. Inhibits papain (K_i>10 ?M), trypsin (K_i>50 ?M), and chymotrypsin (K_i>50 ?M) only at higher concentrations. Exhibits greater selectivity for cysteine proteases of the papain family (K_i= 340 nM, 890 nM, and 1-3 ?M for cathepsin L, cathepsin S, and cathepsin B, respectively).

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
cathepsin K
Product does not compete with ATP.
Reversible: yes
Cell permeable: yes
Target K_i: 22 nM against cathepsin K

警告

Toxicity: Standard Handling (A)

序列

Cbz-Leu-NH-CH?-CO-CH?-NH-Leu-Cbz

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Claveau, D., et al. 2000.Biochem. Pharmacol.60,759.
LaLonde, J.M., et al. 1999.Biochemistry38,862.
Yamashita, D.S., et al. 1997.J. Am. Chem. Soc.119,11351.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₃₁H₄₂N₄O₇
分子量	582.69

半岛bd体育手机客户端性质

质量水平	100
测定	≥95% (HPLC)
形式	lyophilized solid
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze
颜色	off-white
溶解性	methanol: 1 mg/mL DMSO: soluble
运输	wet ice
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable