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Casein Kinase I Inhibitor III, PF-4800567-Calbiochem

品牌
Sigma-Aldrich
货号
218719
规格纯度
The Casein Kinase I Inhibitor III, PF-4800567 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
价格
4330.43 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Casein Kinase I Inhibitor III, PF-4800567-Calbiochem
3-(3-Chlorophenoxymethyl)-1-(tetrahydropyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine, HCl, CKI Inhibitor III, PF-4800567
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable pyrazolopyrimidinylamino compound that acts as a potent, ATP-competitive and reversible inhibitor of CKIε with ~22-fold greater potency over CKIδ (IC50= 32 and 711 nM, respectively) and displays excellent selectivity among 50-kinases, with the only exception of EGFR (69% inhibition at 1 ?M). Shown to preferentially block PER3 (PERIOD3) nuclear translocation in COS7-GFP-PER3-CKIε cells over CKIδ-transfected cells (IC50= 0.13 and 2.65 ?M, respectively), and PER2 degradation in COS7-GFP-PER2-CKIε cells. Unlike Casein Kinase I Inhibitor II, PF-670462 (Cat. No. 218716), PF-4800567 exerts only marginal effect on circadian clock under similar conditions.

包装

5 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Meng, Q.J., et al. 2010.Proc. Natl. Acad. Sci. USA24,15240.
Etchegaray, J.P., et al. 2010.PLoS One5,e10303.
Walton, K.M., et al. 2009.J. Pharmacol. Exp. Ther.330,430.
Badura, L., et al. 2007.J. Pharmacol. Exp. Ther.322,730.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C17H18ClN5O2
分子量 359.81
MDL编号 MFCD22123245

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥99% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 beige
溶解性 DMSO: 50 mg/mL
运输 wet ice
储存温度 2-8℃
SMILES string NC1=NC=NC2=C1C(COC3=CC=CC(Cl)=C3)=NN2C4CCOCC4

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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