Bax Channel Blocker-CAS 335165-69-0-Calbiochem

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一般描述

A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties. Effectively blocks Bid-induced cyctochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel-forming activity (IC₅₀ = 520 nM in a liposome channel assay).
A cell-permeable dibromocarbazole-piperazinyl derivative that displays anti-apoptotic properties. Reported to effectively block Bid-induced cytochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel activity.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
Bax-channel forming activity
Product does not compete with ATP.
Target IC₅₀: 520 nM blocks Bid-induced cyctochrome c release from HeLa cell mitochondria by inhibiting Bax channel-forming activity in a liposome channel assay
Cell permeable: yes
Reversible: no

警告

Toxicity: Carcinogenic / Teratogenic (D)

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Peixoto, P., et al. 2009. Biochem J.423, 381.
Bombrun, A., et al. 2003. J. Med. Chem.46, 4365.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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