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Batimastat-CAS 130370-60-4-Calbiochem

品牌
Sigma-Aldrich
CAS
130370-60-4
货号
196440
规格纯度
Batimastat primarily used in Inhibition.
价格
3439.11 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
130370-60-4
Batimastat-CAS 130370-60-4-Calbiochem
(4-N-Hydroxyamino)-2 R-isobutyl-3 S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide, BB-94
(4-N-Hydroxyamino)-2 R-isobutyl-3 S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide, BB-94
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A Marimastat (Cat. No. 444289) type of peptidyl hydroxamate-based inhibitor that potently inhibits a broad-spectrum of metalloproteinases, including MMP-1, MMP-2, MMP-3/stromelysin, MMP-7/matrilysin, MMP-9, ΔMT1 (MMP-14 without TM domain), ADAM8, and ADAM17/TACE (IC50= 3, 4, 20, 6, 4, 2.08, 51.3, and 19 nM, respectively), by targeting both the substrate binding site and the active-site Zn2+, while being much less potent toward ACE (Angiotensin Converting Enzyme) or α-secretase (IC50= 1.6 and 3.3 ?M, respectively). Batimastat is widely used in studying the involvement of MMPs in cancinogenesis and non-cancer pathological processes both in culturesin vitroand in animalsin vivo.
A Marimastat (Cat. No. 444289) type of peptidyl hydroxamate-based inhibitor that potently inhibits a broad-spectrum of metalloproteinases, including MMP-1, MMP-2, MMP-3/stromelysin, MMP-7/matrilysin, MMP-9, ΔMT1 (MMP-14 without TM domain), ADAM8, and ADAM17/TACE (IC50= 3, 4, 20, 6, 4, 2.08, 51.3, and 19 nM, respectively), by targeting both the substrate binding site and the active-site Zn2+, while being much less potent toward ACE (Angiotensin Converting Enzyme) or α-secretase (IC50= 1.6 and 3.3 ?M, respectively). Batimastat is widely used in studying the involvement of MMPs in cancinogenesis and non-cancer pathological processes both in culturesin vitroand in animalsin vivo. Also available as a 25 mM solution in DMSO (Cat. No. 508408).

包装

5 mg in Glass bottle
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Schlomann, U., et al. 2002.J. Biol. Chem.277,48210.
Whittaker, M., et al. 1999.Chem. Rev.99,2735.
Parvathy, S., et al. 1998.Biochemistry37,1680.
Parvathy, S., et al. 1998.FEBS Lett.431,63.
Yamamoto, M., et al. 1998.J. Med. Chem.41,1209.
Moss, M.L., et al. 1997.Nature385,733.
Eccles, S.A., et al. 1996.Cancer Res.56,2815.
Brown, P.D. 1995.Advan. Enzyme Regul.35,293.
Wang, X., et al. 1994.Cancer Res.54,4726.
Davies, B., et al. 1993.Cancer Res.53,2087.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C23H31N3O4S2
分子量 477.64
MDL编号 MFCD00866533

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 off-white
溶解性 DMSO: 50 mg/mL
运输 ambient
储存温度 2-8℃
InChI 1S/C23H31N3O4S2/c1-15(2)12-17(18(22(28)26-30)14-32-20-10-7-11-31-20)21(27)25-19(23(29)24-3)13-16-8-5-4-6-9-16/h4-11,15,17-19,30H,12-14H2,1-3H3,(H,24,29)(H,25,27)(H,26,28)/t17-,18+,19+/m1/s1
InChI key XFILPEOLDIKJHX-QYZOEREBSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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