AG 1295-CAS 71897-07-9-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, reversible, ATP-competitive, and selective inhibitor of platelet-derived growth factor (PDGF) receptor kinase (IC₅₀= 500 nM) and PDGF-dependent DNA synthesis (IC₅₀= 2.5 ?M) in Swiss/3T3 cells. Has no effect on EGF receptor autophosphorylation and shows only a weak effect on EGF- or insulin-stimulated DNA synthesis. A potent blocker of smooth muscle cell proliferation.
Selectively inhibits platelet-derived growth factor (PDGF) receptor kinase (IC₅₀= 500 nM) and the PDGF-dependent DNA synthesis (IC₅₀= 2.5 ?M) in Swiss 3T3 cells. Has no effect on epidermal growth factor (EGF) receptor autophosphorylation and shows only a weak effect on EGF- or insulin-stimulated DNA synthesis.

包装

5 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Target IC₅₀: 500 nM against PDGFR kinase
Product competes with ATP.
Reversible: yes
Primary Target
PDGFR kinase

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Banai, S., et al. 1998.Circulation97,1960.
Levitzki, A., and Gazit, A. 1995.Science267,1782.
Kovalenko, M., et al. 1994.Cancer Res.54,6106.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C16H14N2
分子量	234.30

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	white
溶解性	DMSO: 10 mg/mL dichloromethane: soluble
运输	ambient
储存温度	?20℃
InChI	1S/C16H14N2/c1-11-8-14-15(9-12(11)2)18-16(10-17-14)13-6-4-3-5-7-13/h3-10H,1-2H3
InChI key	FQNCLVJEQCJWSU-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3