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位置: 首页> 品牌> Sigma-Aldrich> [6]-Gingerol,Zingiber officinale-CAS 23513-14-6-Calbiochem

[6]-Gingerol,Zingiber officinale-CAS 23513-14-6-Calbiochem

品牌
Sigma-Aldrich
CAS
23513-14-6
货号
345868
规格纯度
An antitumor, apoptosis-inducing compound of the ginger family that blocks EGF-induced cell transformation by inhibiting the activation of Activator Protein-1 (AP-1).
价格
2209 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
23513-14-6
[6]-Gingerol, Zingiber officinale-CAS 23513-14-6-Calbiochem
1-(4'-Hydroxy-3'-methoxyphenyl)-5-hydroxy-3-decanone
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Phytochemical compound isolated from the extract of rhizome of ginger. Along with other related compounds found in ginger extracts inhibits prostaglandin and leukotriene biosynthesis through the suppression of 5-lipoxygenase and prostaglandin synthetase. Also exhibits anti-tumor and apoptosis-inducing effects. Blocks EGF-induced cell transformation by inhibiting the activation of Activator protein-1 (AP-1). Shown to inhibit the EGF-induced, sequence-specific DNA-binding of AP-1. Does not effect EGF-induced phosphorylation of ERK or p38 kinases. Also increases the Ca2+-ATPase activity of the sarcoplasmic reticulum (EC50= 4 ?M).
An antitumor, apoptosis-inducing compound of the ginger family that blocks EGF-induced cell transformation by inhibiting the activation of Activator Protein-1 (AP-1). Also increases the Ca2+-ATPase activity in cardiac sarcoplasmic reticulum (EC50= 4 ?M) and increases Ca2+uptake.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

EC50 = 4 ?M increasing the Ca2+-ATPase activity in cardiac sarcoplasmic reticulum
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Activator Protein-1 (AP-1)

警告

Toxicity: Harmful (C)

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months -20°C.

其他说明

Bode, A.M., et al. 2001.Cancer Res.61,850.
Antipenko, A.Y., et al. 1999.J. Pharmacol. Exp. Ther.290,227.
Park, K.K.,et al. 1998.Cancer Lett.129,139.
Kobayashi, M., et al. 1987.Biochim. Biophys. Acta903,96.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C17H26O4
分子量 294.39
MDL编号 MFCD00210507

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 oil
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 pale yellow
溶解性 DMSO: 5 mg/mL
运输 ambient
储存温度 ?20℃
InChI 1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-17(21-2)16(20)11-13/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3
InChI key LPRPIMHDDACJHT-UHFFFAOYSA-N

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H315 - H319 - H335
预防措施声明 P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
危险分类 Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官 Respiratory system
储存分类代码 10 - Combustible liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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