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位置: 首页> 品牌> Sigma-Aldrich> 4-Hydroxyphenylretinamide-CAS 65646-68-6-Calbiochem

4-Hydroxyphenylretinamide-CAS 65646-68-6-Calbiochem

品牌
Sigma-Aldrich
CAS
65646-68-6
货号
390900
规格纯度
A synthetic amide of all-transretinoic acid (RA) that displays reduced toxicity relative to RA while maintaining significant biological activity.
价格
2671.25 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
65646-68-6
4-Hydroxyphenylretinamide-CAS 65646-68-6-Calbiochem
Fenretinide, 4HPR, N-(4-Hydroxyphenyl)-all- transRetinamide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A synthetic amide of all-transretinoic acid (RA) that displays reduced toxicity relative to RA while maintaining significant biological activity. Active in the prevention and treatment of a variety of neoplasms in animals. Inhibits human breast cancer, prostate adenocarcinoma, and ovarian carcinoma cell proliferation. Inhibits angiogenesis as well as endothelial cell motility and tubule formation. Induces apoptosis in malignant hemopoietic cell lines.
A synthetic amide of all-transretinoic acid (RA) that displays reduced toxicity relative to RA while maintaining significant biological activity. Active in the prevention and treatment of a variety of neoplasms in animals. Inhibits proliferation in cell lines of human breast cancer, prostate adenocarcinoma, and ovarian carcinoma. Inhibits angiogenesis, as well as endothelial cell motility and tubule formation. Induces apoptosis in malignant hemopoietic cell lines.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
Active in the prevention and treatment of a variety of neoplasms in animals.
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Formelli, F., et al. 1996.FASEB J.10,1014.
Naik, H.R., et al. 1995.Adv. Pharmacol.33,315.
Delia, D., et al. 1993.Cancer Res.53,6036.
Pienta, K.J., et al. 1993.Cancer Res.53,224.
Grubbs, C.J., et al. 1990.Anticancer Res.10,661.
McCarthy, D.J., et al. 1987.Cancer Res.47,5014.
Moon, R.C., et al. 1979.Cancer Res.39,1339.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C26H33NO2
分子量 391.55
MDL编号 MFCD00792674

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥97% (TLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 orange
溶解性 DMSO: 25 mg/mL
acetone: soluble
ethanol: soluble
运输 ambient
储存温度 ?20℃
InChI 1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+
InChI key AKJHMTWEGVYYSE-FXILSDISSA-N

安全信息

象形图 GHS07GHS08
警示用语: Danger
危险声明 H302 + H312 + H332 - H315 - H319 - H335 - H360
预防措施声明 P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
危险分类 Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
靶器官 Respiratory system
储存分类代码 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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