Pifithrin-α,p-Nitro, Cyclic-CAS 60477-38-5-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED₅₀= 30 nM in protecting etoposide-induced cortical neuron death) and 50% longer half-life (t_1/2= 6h in neuron culture medium at 37°C) than Pifithrin-α (Cat. No. 506132). However, despite itsin vitroefficacy, this inhibitor is not effective when adminstered in ratsin vivo. Forin vivoapplications, please consider Pifithrin-α,p-Nitro (Cat. No. 506152).
A cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED₅₀= 30 nM in protecting etoposide-induced cortical neuron death) and 50% longer half-life (t_1/2= 6h in neuron culture medium at 37°C) than Pifithrin-α (Cat. No. 506132). However, despite itsin vitroefficacy, this inhibitor is not effective when adminstered in ratsin vivo. Forin vivoapplications, please consider Pifithrin-α,p-Nitro (Cat. No. 506152).

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
ED50 = 30 nM in protecting etoposide-induced cortical neuron death
Primary Target
p53
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Pietrancosta, N., et al. 2006.J. Med. Chem.49,3645.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C15H13N3O2S
分子量	299.35

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	yellow
溶解性	DMSO: 2.5 mg/mL ethanol: 250 μg/mL
运输	ambient
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable