CDC25 Phosphatase Inhibitor I, BN82002-CAS 396073-89-5-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeableortho-hydroxybenzylamino compound that displays antitumor properties. Acts as a potent, selective and irreversible inhibitor of CDC25 phosphatase family (IC₅₀= 2.4, 3.9, 6.3, 5.4, and 4.6 ?M for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). Displays ~20-fold greater selectivity for CDC25 phosphatases over CD45 tyrosine phosphatase. Shown to delay cell cycle progressionin vitro(IC₅₀= ~7.2-32.6 ?M), and reduces tumor growth in athymic mice xenografted with the human pancreatic cells MIA PaCa-2 (15 mg/kg, i.p. route).
A cell-permeableortho-hydroxybenzylamino compound that displays anti-tumor properties. Acts as a potent, selective, and irreversible inhibitor of CDC25 phosphatase family (IC₅₀= 2.4, 3.9, 6.3, 5.4, and 4.6 ?M for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). Displays ~20-fold greater selectivity for CDC25 phosphatases compared to CD45 tyrosine phosphatase. Shown to delay cell cycle progressionin vitro(IC₅₀in the range of 7.2-32.6 ?M), and reduces tumor growth in athymic mice xenografted with the human pancreatic cell MIA PaCa-2 (15 mg/kg, i.p. route).

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC₅₀: 2.4, 3.9, 6.3, 5.4, and 4.6 ?M for CDC25 phosphatase family 25A, 25B2, 25B3, 25C, and 25C-cat, respectively
Primary Target
CDC25A
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution.

其他说明

Brezak, M.C., et al. 2004.Cancer Res.64,3320.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

半岛bd体育手机客户端 性质

安全信息