ATM/ATR Kinase Inhibitor-CAS 905973-89-9-Calbiochem

品牌

Sigma-Aldrich

CAS

905973-89-9

货号

118501

包装型号

5 MG, The ATM/ATR Kinase Inhibitor, also referenced under CAS 905973-89-9, controls the biological activity of ATM/ATR Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Depho

规格纯度

The ATM/ATR Kinase Inhibitor, also referenced under CAS 905973-89-9, controls the biological activity of ATM/ATR Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

价格

3806.77 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

905973-89-9
ATM/ATR Kinase Inhibitor-CAS 905973-89-9-Calbiochem
CGK 733

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A cell-permeable thiourea compound that selectively inhibits the kinase activity of ATM and ATR (IC₅₀= ~200 nM) without significant effect against other PIKK family members (PI 3-K, mTOR, and DNA-PK) or kinases that are known to phosphorylate p53 (ERK, CK1, Cdk2, JNK, PKC, CAK, Chk1, PKR, and p38). Shown to reverse senescence in human primary BJ and HMEC cells. Unlike LY 294002 (Cat. No. 440202 and 440204), this inhibitor does not interfere with cellular PI 3-K/PDK1/Akt signaling pathway.
A cell-permeable thiourea compound that selectively inhibits the kinase activity of ATM and ATR (IC₅₀~ 200 nM) without significant effect against other PIKK family members (PI3K, mTOR, and DNA-PK) or kinases that are known to phosphorylate p53 (ERK, CK1, Cdk2, JNK, PKC, CAK, Chk1, PKR, and p38). Shown to reverse senescence in human primary BJ and HMEC cells. Unlike LY 294002 (Cat. No. 440202 and 440204), this inhibitor does not interfere with cellular PI3K-PDK1-Akt signaling pathway.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
ATM/ATR
Product does not compete with ATP.
Reversible: no
Target IC₅₀: ~200 nM against ATM and ATR

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Goldstein, M., et al. 2008.Toxicol. Appl. Pharmacol.in press.
Crescenzi, E., et al. 2008.Clin. Cancer Res.14,1877.
Cruet-Hennequart, S., et al. 2008.DNA Repair7,582.
Won, J., et al. 2006.Nat. Chem. Biol.2,369.(RETRACTED)

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₃H₁₈Cl₃FN₄O₃S
分子量	555.84

半岛bd体育手机客户端性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze protect from light
颜色	pale yellow
溶解性	DMSO: 5 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C23H18Cl3FN4O3S/c24-23(25,26)21(30-22(35)28-16-11-12-17(27)18(13-16)31(33)34)29-20(32)19(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13,19,21H,(H,29,32)(H2,28,30,35)
InChI key	HLCDNLNLQNYZTK-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable