PTP CD45 Inhibitor-CAS 345630-40-2-Calbiochem

品牌

Sigma-Aldrich

CAS

345630-40-2

货号

540215

包装型号

5 MG, The PTP CD45 Inhibitor, also referenced under CAS 345630-40-2, controls the biological activity of PTP CD45. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation

规格纯度

The PTP CD45 Inhibitor, also referenced under CAS 345630-40-2, controls the biological activity of PTP CD45. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

价格

3124.36 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

345630-40-2
PTP CD45 Inhibitor-CAS 345630-40-2-Calbiochem
N-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethyl-propionamide, PTPase CD45 Inhibitor, Protein Tyrosine Phosphatase CD45 Inhibitor, SF1670, PTP Inhibitor XIX, PTP1B Inhibitor VI, PTPN2/TCPTP Inhibitor, SHP1 Inhibitor VII, YPTP1 Inhibitor, YOP Inh
N-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethyl-propionamide, PTPase CD45 Inhibitor, Protein Tyrosine Phosphatase CD45 Inhibitor, SF1670, PTP Inhibitor XIX, PTP1B Inhibitor VI, PTPN2/TCPTP Inhibitor, SHP1 Inhibitor VII, YPTP1 Inhibitor, YOP Inhi

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC₅₀= 200 nM usingpNPP as the substrate, 3.8 ?M for CD45lck, >30 ?M for PTP1Blck) that displays anti-proliferative properties. Also reported to potently block T-cell receptor-mediated proliferation (IC₅₀= 100 nM). Shown to be less cytotoxic (CC₅₀= 3.5 ?M) than other 1,2-naphthalenedione analogs. The phenanthrenedione group does not function as a thiol oxidizing agent. One of the most potent inhibitor of phosphatase tensin homolog deleted on chromosome 10 (PTEN) that enhances PIP3 signaling in a variety of cells and improves the efficacy of granulocyte transfusion in murine models of neutropenia-related pneumonia.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC₅₀: 200 nM or 3.8 ?M against CD45 using pNPP or phosphorylated Ick505 peptide as a substrate, respectively
Product does not compete with ATP.
Reversible: yes
Primary Target
CD45 using pNPP as a substrate

警告

Toxicity: Harmful (C)

其他说明

Li, Y., et al. 2011.Blood117,6702.
Urbanek, R.A., et al. 2001.J. Med. Chem.44,1777.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₉H₁₇NO₃
分子量	307.34

半岛bd体育手机客户端性质

质量水平	100
测定	≥97% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze protect from light
颜色	red-violet
溶解性	DMSO: 5 mg/mL ethanol: 5 mg/mL
运输	wet ice
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable