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MK2a Inhibitor-CAS 41179-33-3-Calbiochem

品牌
Sigma-Aldrich
CAS
41179-33-3
货号
475863
规格纯度
The MK2a Inhibitor, also referenced under CAS 41179-33-3, controls the biological activity of MK2a. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
价格
3945.15 *本价格含增值税费
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半岛bd体育手机客户端 名称:
41179-33-3
MK2a Inhibitor-CAS 41179-33-3-Calbiochem
Mitogen-activated protein kinase-activated protein kinase 2a Inhibitor, 4-(2'-Fluorobiphenyl-4-yl)-N-(4-hydroxyphenyl)-butyramide, CMPD1, MAPKAPK2a Inhibitor
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A reversiblep-amidophenolic compound that selectively inhibits the phosphorylation of MK2a (mitogen-activated protein kinase-activated protein kinase 2a; Kiapp= 330 nM) by p38α in a non-ATP-competitive manner. Does not block the kinase activity of p38α towards the other two known p38 substrates, MBP and ATF-2.
A non-ATP-competitive, reversible, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-activated protein kinase 2a) phosphorylation (Kiapp= 330 nM). Does not inhibit p38α-mediated phosphorylation of the the other two known p38 substrates, MBP and ATF-2.

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Kiapp = 330 nM against mitogen-activated protein kinase-activated protein kinase 2a (MK2a)
Product does not compete with ATP.
Primary Target
Mk2α
Cell permeable: no
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Davidson, W., et al. 2004.Biochemistry43,11658.
Lukas, S.M., et al. 2004.Biochemistry43,9950.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C22H20FNO2
分子量 349.40

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 pale yellow
溶解性 DMSO: 5 mg/mL
ethanol: 5 mg/mL
运输 ambient
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 1

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