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位置: 首页> 品牌> Sigma-Aldrich> Cdk4 Inhibitor II, NSC 625987-CAS 141992-47-4-Calbiochem

Cdk4 Inhibitor II, NSC 625987-CAS 141992-47-4-Calbiochem

品牌
Sigma-Aldrich
CAS
141992-47-4
货号
219477
规格纯度
The Cdk4 Inhibitor II, NSC 625987, also referenced under CAS 141992-47-4, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
价格
2671.25 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
141992-47-4
Cdk4 Inhibitor II, NSC 625987-CAS 141992-47-4-Calbiochem
1,4-Dimethoxyacridine-9(10H)-thione
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A potent, reversible, and substrate-competitive inhibitor of Cdk4/cyclin D1 (IC50= 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC50>100 ?M).
A thioacridone compound that acts as a reversible and potent substrate-competitive inhibitor of Cdk4/cyclin D1 (IC50= 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC50>100 ?M).

包装

5 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Primary Target
CDK4/D1
Target IC50: 200 nM against CDK4/D1
Product does not compete with ATP.
Cell permeable: no
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Kubo, A., et al. 1999.Clin. Cancer Res.5,4279.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C15H13NO2S
分子量 271.33
MDL编号 MFCD08276925

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥95% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 brown
溶解性 ethanol: 2.5 mg/mL
DMSO: 25 mg/mL
运输 ambient
储存温度 2-8℃
InChI 1S/C15H13NO2S/c1-17-11-7-8-12(18-2)14-13(11)15(19)9-5-3-4-6-10(9)16-14/h3-8H,1-2H3,(H,16,19)
InChI key KFAKESMKRPNZTM-UHFFFAOYSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3

Sigma-Aldrich

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