Casein Kinase II Inhibitor III, TBCA-CAS 934358-00-6-Calbiochem

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一般描述

A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC₅₀= 110 nM, K_i= 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC₅₀= 7.7 ?M). Also available as a 25 mM solution in DMSO (Cat. No. 218861).
A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC₅₀= 110 nM, K_i= 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC₅₀= 7.7 ?M).

包装

5 mg in Plastic Bag(s)
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target K_i: 77 nM against Casein Kinase II
Reversible: no
Product competes with ATP.

警告

Toxicity: Irritant (B)

其他说明

Pagano, M.A., et al. 2006.Chembiochem8,129

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

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