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位置: 首页> 品牌> Sigma-Aldrich> LSD1 Inhibitor VII, SP-2509-CAS 1423715-09-6-Calbiochem

LSD1 Inhibitor VII, SP-2509-CAS 1423715-09-6-Calbiochem

品牌
Sigma-Aldrich
CAS
1423715-09-6
货号
5.09703
规格纯度
A cell-permeable, potent, selective, reversible inhibitor of Lysine-Specific Demethylase 1 (LSD1; IC50= 13 nM; Ki= 31 nM).
价格
2428.75 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
1423715-09-6
LSD1 Inhibitor VII, SP-2509-CAS 1423715-09-6-Calbiochem
BHC110 Inhibitor VII, Histone Lysine Demethylase Inhibitor XIV, KIAA1718 Inhibitor VII, LSD Inhibitor VII, SP-2509
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, lysine-specific demethylase 1 (LSD1) active site-targeting phenethylidene-benzohydrazide that inhibits LSD1 activity (IC50= 13 nM) in a reversible and substrate non-competitive (Ki= 34 nM) manner, while inhibiting CYP3A4 only at much higher concentrations (IC50= 2.61 ?M) and displaying little or no potency towards CYP1A2/2C9/2C19/2D6. MAO-A/B, D-lactate dehydrogenase, glucose oxidase, and hERG (IC50≥8.0 ?M). Shown to enhance histone H3 Lys9 dimethylation (H3K9me2) in androgen-dependent prostate cancer VCaP cultures (1 to 10 ?M) and effectively inhibits LSD1-dependent cancer growth (IC50in nM = 329/SK-N-MC, 356/AN3 Ca, 429/HT29, 468/MIA PaCa-2, 489/BT-20, 612/HER218, 614/HCT 116, 637/MCF-7, 649/T-47D; 96 h).
A cell-permeable phenethylidene-benzohydrazide compound that acts as a potent, selective, reversible, and non-competitive inhibitor of Lysine-Specific Demethylase 1 (LSD1; IC50= 13 nM; Ki= 31 nM). Exhibits excellent selectivity over monoamine oxidases A and B (IC50>300 ?M), lactate dehydrogenase, glucose oxidase, hERG, CYP1A2, CYP2D6 (IC50≥ 10 ?M), CYP2C9 (IC50= 8.04 ?M) and CYP2C19 (IC50= 9.76 ?M). Inhibits CYP3A4 only at >200-fold higher concentration. Reduces the proliferation of several cancer cell lines, including AN3 Ca, BT-20, MCF-7, T-47D, HT29, MIA PaCa-2 and SK-N-MC (IC50= 356, 489, 637, 649, 429, 468 and 329 nM, respectively).

生化/生理作用

Cell permeable: yes
Reversible: yes
Primary Target
LSD1

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Fiskus, W., et al. 2014.Leukemia28,2155.
Sorna, V., et al. 2013.J. Med. Chem.56,9496.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C19H20ClN3O5S
分子量 437.90

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 off-white
溶解性 DMSO: 100 mg/mL
储存温度 2-8℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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