InSolution MIF Antagonist, ISO-1-CAS 478336-92-4-Calbiochem

品牌

Sigma-Aldrich

CAS

478336-92-4

货号

5.05225

包装型号

10 MG

规格纯度

价格

2070.22 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

478336-92-4
InSolution MIF Antagonist, ISO-1-CAS 478336-92-4-Calbiochem
( S, R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester, Methyl 2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate, Macrophage Migration Inhibitory Factor Antagonist, ISO-1
( S, R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester, Methyl 2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate, Macrophage Migration Inhibitory Factor Antagonist, ISO-1

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A cell-permeable isoxazoline compound that displays anti-inflammatory properties. Inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC₅₀= 7 ?M for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE₂and COX-2 in human monocytes and arachidonic acid in RAW 264.7 macrophages. Shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model.

生化/生理作用

Cell permeable: yes
Primary Target
MIF dopachrome tautomerase

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

外形

A 50 mM (10 mg/850 ?L) sterile-filtered solution of MIF Antagonist, ISO-1 (Cat. No. 475837) in DMSO.

重悬

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 1 year at -70°C.

其他说明

Cvetkovic, I., et al. 2005.Endocrinology146,2942.
Lubetsky, J.B., et al. 2002.J. Biol. Chem.277,24976.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₂H₁₃NO₄
分子量	235.24

半岛bd体育手机客户端性质

质量水平	100
测定	≥95% (HPLC)
形式	liquid
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light
储存温度	?70℃

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 1
闪点(F)	188.6 °F - (refers to pure substance)
闪点(C)	87 ℃ - (refers to pure substance)