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位置: 首页> 品牌> Sigma-Aldrich> InSolution Ginkgolic Acid (15:1)-CAS 22910-60-7-Calbiochem

InSolution Ginkgolic Acid (15:1)-CAS 22910-60-7-Calbiochem

品牌
Sigma-Aldrich
CAS
22910-60-7
货号
5.08197
规格纯度
A 25 mM (2 mg/231 μl) sterile-filtered solution of Ginkgolic Acid (15:1) in DMSO.
价格
2313.1 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
22910-60-7
InSolution Ginkgolic Acid (15:1)-CAS 22910-60-7-Calbiochem
Histone Acetyltransferase Inhibitor VI, PCAF Inhibitor II, HAT Inhibitor VI, SUMOylation Inhibitor, ( Z)-6-(Pentadec-8-enyl)-2-hydroxybenzoic acid, ( Z)-2-Hydroxy-6-(pentadec-8-enyl)benzoic acid
Histone Acetyltransferase Inhibitor VI, PCAF Inhibitor II, HAT Inhibitor VI, SUMOylation Inhibitor, ( Z)-6-(Pentadec-8-enyl)-2-hydroxybenzoic acid, ( Z)-2-Hydroxy-6-(pentadec-8-enyl)benzoic acid
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable anacardic acid (Cat. No. 172050) analog that inhibits protein SUMO (Cat. No. 662037, 662039, and 662042) modification (IC50= 3.0 ?M using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. No. 662073 and 662074) and interfering with E1-SUMO intermediate formation independent of E1 active site cysteine. Both ginkgolic acid and anacardic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins, including p53, in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although both compounds are shown to inhibit histone lysine acetylation by PCAF (Cat. No. 124026) in cell-free acetylase assays.

生化/生理作用

Cell permeable: yes
Primary Target
SUMO-activating enzyme E1
Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

外形

A 25 mM (2 mg/231 ?l) sterile-filtered solution of Ginkgolic Acid (15:1) (Cat. No. 345887) in DMSO.

重悬

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.

其他说明

Fukuda, I., et al. 2009.Chem. Biol.16,133.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C22H34O3
分子量 346.50
MDL编号 MFCD03093717

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 liquid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light
储存温度 ?70℃
InChI 1S/C22H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h7-8,15,17-18,23H,2-6,9-14,16H2,1H3,(H,24,25)/b8-7-
InChI key YXHVCZZLWZYHSA-FPLPWBNLSA-N

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 2
闪点(F) 188.6 °F - (refers to pure substance)
闪点(C) 87 ℃ - (refers to pure substance)

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