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位置: 首页> 品牌> Sigma-Aldrich> HDAC6 Inhibitor II, BRD9757-CAS 1423058-85-9-Calbiochem

HDAC6 Inhibitor II, BRD9757-CAS 1423058-85-9-Calbiochem

品牌
Sigma-Aldrich
CAS
1423058-85-8
货号
5.05760
包装型号
规格纯度
价格
2289.97 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
1423058-85-8
HDAC6 Inhibitor II, BRD9757-CAS 1423058-85-9-Calbiochem
N-Hydroxycyclopent-1-enecarboxamide, HDAC Inhibitor XVI, Histone Deacetylase Inhibitor XVI
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, low molecular weight hydroxamate compound that acts as a potent histone deacetylase class IIb HDAC6-selective inhibitor (IC50= 30 nM), while inhibiting class I HDAC1/2/3/8 only at higher concentrations (IC50= 0.638, 1.79, 0.694, and 1.09 ?M, respectively) and exhibiting much reduced potency against class IIa HDAC4/5/7/9 (IC50>12.61 ?M). Shown to selectively upregulate HDAC6 substrate α-tubulin acetylation in HeLa cells (10 & 30 ?M; 24 h) without inducing histone H3 acetylation increase seen with another HDAC6-selective inhibitor Tubastatin A (Cat. No. 382187). Unlike other Zinc-binding group-containing HDAC inhibitors, BRD9757 does not contain an apparent selectivity-imparting capping structure linked to its hydroxamate.
A cell-permeable, low molecular weight hydroxamate compound that acts as a potent histone deacetylase class IIb HDAC6-selective inhibitor (IC50= 30 nM), while inhibiting class I HDAC1/2/3/8 only at higher concentrations (IC50= 0.638, 1.79, 0.694, and 1.09 ?M, respectively) and exhibiting much reduced or little potency against class IIa HDAC4/5/7/9 (IC50= 21.80, 18.32, 12.61, and >33.33 ?M, respectively). Shown to selectively upregulate HDAC6 substrate α-tubulin acetylation level in HeLa cells (10 & 30 ?M; 24 h) without inducing detectable histone H3 acetylation increase seen in cells treated with another HDAC6-selective inhibitor Tubastatin A (Cat. No. 382187) or the general HDAC inhibitor SAHA. BRD9757 does not contain an apparent selectivity-imparting capping structure linked to the zinc-binding hydroxamate as seen in other ZBG- (Zinc binding group) containing HDAC inhibitors.

生化/生理作用

Cell permeable: yes
Primary Target
HDAC6
Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Wagner, F.F., et al. 2013.J. Med. Chem.56,1772.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C6H9NO2
分子量 127.14

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
颜色 pale orange
溶解性 DMSO: 100 mg/mL
储存温度 2-8℃

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H319 - H412
预防措施声明 P264 - P273 - P280 - P305 + P351 + P338 - P337 + P313 - P501
危险分类 Aquatic Chronic 3 - Eye Irrit. 2
储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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