半岛bd体育手机客户端 说明
一般描述
An extremely selective dopamine D2receptor agonist (Ki= 9 nM). Commonly used in Parkinson′s Disease models and to reproduce cocaine′s discriminative stimulus effects. Sumanirole has greater than 200-fold selectivity for the D2receptor subtype versus the other dopamine receptor subtypes in radioligand binding assays. In cell-based assays, sumanirole is a fully efficacious agonist, with EC50values between 17 and 75 nM. In animals, sumanirole elicits many physiological responses attributed to D2-like receptor function.
警告
Toxicity: Standard Handling (A)
其他说明
Achat-Mendes, C. et al., 2010.J. Pharmacol. Exp. Ther.334,556.
McCall, R. B. et al., 2005.J. Pharmacol. Exp. Ther.314,1248.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C11H13N3O · xC4H4O4 |
分子量 | 203.24 (free base basis) |
MDL编号 | MFCD09832637 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | solid |
效能 | 9 nM Ki |
manufacturer/tradename | Calbiochem? |
储存条件 | OK to freeze protect from light |
颜色 | off-white |
溶解性 | DMSO: 16 mg/mL |
储存温度 | ?20℃ |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich