Peroxiredoxin Inhibitor, Conoidin A-CAS 18080-67-6-Calbiochem

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一般描述

A cell-permeable dibromomethylquinoxaline-dioxide compound with nematicidal properties that covalently binds to the peroxidatic cysteine of peroxiredoxin II inToxoplasma gondii(TgPrxII) and irreversibly blocks its hyperperoxidation activity (IC₅₀= 23 ?M). Also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 inAncylostoma ceylanicumand human PrxII and PrxIV to inhibit their catalytic activity with similar efficiency. Ineffective towards mitochondrial hPrxIII.
A cell-permeable dibromomethylquinoxaline-dioxide compound with nematicidal properties that covalently binds to the peroxidatic cysteine of peroxiredoxin II inToxoplasma gondii(TgPrxII) and irreversibly blocks its hyperperoxidation activity (IC₅₀= 23 ?M). Also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 inAncylostoma ceylanicumand human PrxII and PrxIV to inhibit their catalytic activity with similar efficiency. Ineffective towards mitochondrial hPrxIII.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

生化/生理作用

Cell permeable: yes
Reversible: no
Primary Target
Peroxiredoxin
Target IC₅₀: 23 ?M for blocking TgPrxII hyperperoxidation activity

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
Use only fresh DMSO for reconstitution.

其他说明

Nguyen, J.B., et al. 2013.Chem. Biol.20,991.
Haraldsen, J. D., et al. 2009.Org. Biomol. Chem.7,3040.
Carey, K.L., et al. 2004.Proc. Natl. Acad. Sci. USA101,7433.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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