NS309-CAS 18711-16-5-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A potent activator of Ca2+ -activated K+ channels of SK and IK types but not BK type channels. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell. NS309 blocks L-type Calcium channels with IC₅₀= 10 ?M/L. Recently, this compound has been shown to produce endothelium-dependent hyperpolarizations in guinea pig carodid arteries by opening KCa2.3 and KCa3.1 channels demonstrating a new therapeutic option for treating hypertension.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
A potent activator of Ca2+ -activated K+ channels of SK and IK types but not BK type channels. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell. NS309 blocks L-type Calcium channels with IC₅₀= 10 ?M/L. Recently, this compound has been shown to produce endothelium-dependent hyperpolarizations in guinea pig carodid arteries by opening KCa2.3 and KCa3.1 channels demonstrating a new therapeutic option for treating hypertension.

生化/生理作用

Primary Target
Ca2+-activated K+ channels

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Leurangue, V. et al. 2008.Naunyn Schmiedebergs Arch. Pharmacol.377,101.
Morimura, K. et al. 2006.J. Pharmacol. Sci.100,237.
Strobaek, D. et al. 2004.Biochim. Biophys. Acta.1665,1.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C8H4Cl2N2O2
分子量	231.04
MDL编号	MFCD06798346

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	yellow
溶解性	DMSO: 100 mM
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable