Lipid Uptake Inhibitor, ML278-Calbiochem

品牌

Sigma-Aldrich

货号

5.38769

包装型号

5 MG

规格纯度

价格

1272.2 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

Lipid Uptake Inhibitor, ML278-Calbiochem
3,5-Dimethoxy-N-(4-(1-(2-methoxyacetyl)indolin-5-yl)thiazol-2-yl)benzamide, SR-BI inhibitor ML278

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A cell-permeable, non-toxic, indolinyl-thiazole based compound that acts as a highly potent, reversible inhibitor of lipid uptake via scavenger receptor class B type I (SR-BI; IC₅₀= 6 nM). Shown to block the uptake of [³H] labeled cholesteryl oleate ester ([³H]CE) from [³H]CE-HDL (IC₅₀= 7 nM). Exhibits high selectivity when tested against a panel of 67 different receptors and secondary targets (at 10 ?M). Displays excellent stability in human plasma (99% remaining after 5 h, with 94% plasma protein bound) and mouse liver microsomes (75% remaining after 1 h).
A cell-permeable, non-toxic, indolinyl-thiazole based compound that acts as a highly potent, reversible inhibitor of lipid uptake via scavenger receptor class B type I (SR-BI; IC₅₀= 6 nM). Shown to block the uptake of [³H] labeled cholesteryl oleate ester ([³H]CE) from [³H]CE-HDL (IC₅₀= 7 nM). Exhibits high selectivity when tested against a panel of 67 different receptors and secondary targets (at 10 ?M). Displays excellent stability in human plasma (99% remaining after 5 h, with 94% plasma protein bound) and mouse liver microsomes (75% remaining after 1 h).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

生化/生理作用

Cell permeable: yes
Primary Target
scavenger receptor class B type I
Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Dockendorff, C., et al. 2015.ACS Med. Chem. Lett.6,375.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₃H₂₃N₃O₅S
分子量	453.51

半岛bd体育手机客户端性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
效能	6 nM IC₅₀
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze protect from light
颜色	light yellow
溶解性	DMSO: 5 mg/mL
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable